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Hepatic and renal insufficiency; elderly; psychiatric disorders; history of drug abuse. Might impair capacity to drive or function equipment. Limit cure duration toZopiclone exerts its motion by binding to the benzodiazepine receptor complicated and modulation of the GABABZ receptor chloride channel macromolecular intricate. Both equally zopiclone

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Povišena je koncentracija diazepama u plazmi usled inhibicije CYP3A4 metaboličkog puta. U studiji kod zdravih dobrovoljaca primena two hundred mg itrakonazola dnevno tokom 4 dana povećala je PIK pojedinačne oralne doze od 5 mg diazepama za oko 15%, ali ova interakcija nije bila od kliničkog značaja, što je potvrđeno psihomotornim testovima.

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